the SCOPE-ITSCC metastases study, a prospective multi-center study

Published: 16 January 2024| Version 1 | DOI: 10.17632/458kxcvxcg.1
Contributor:
Estella de Jong

Description

Solid organ transplant recipients (SOTRs) are believed to have an increased risk of metastatic cutaneous squamous-cell carcinoma (cSCC), but reliable data are lacking regarding the precise incidence and associated risk factors. Of 514 SOTRs who presented with 623 primary cSCCs, 37 developed metastases with a 2-year patient-based cumulative incidence of 6.2%. Risk factors for metastases included location in the head and neck area, local recurrence, size >2cm, clinical ulceration, poor differentiation grade, perineural invasion and deep invasion. A high-stage tumor that is also ulcerated showed the highest risk of metastasis, with a 2-year cumulative incidence of 46.2% (31.9% – 68.4%).

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Institutions

Leids Universitair Medisch Centrum

Categories

Squamous Cell Carcinoma, Patient with Solid Organ Transplantation

Funding

European Academy of Dermatology and Venereology

Licence