Effect of Candesartan in a rat model having memory impairment induced by electromagnetic waves.
Rapid growing of mobile phones users has raised about the possible effects of these electromagnetic field-radiofrequency (EMF-RF) on human health. Many studies have examined the effect of these EMF-RF on biological systems, but the results are still contradictory and controversial. In addition to EMF-RF, over-activation of angiotensin type 1 receptor (AT1R) has been associated with cognitive decline, incidence and progression of neurodegenerative diseases. Candesartan, an AT1R blocker, is well recognized for treatment of hypertension. However, its effect on cognitive functions such as spatial and recognition memory remains elusive. Thus, young rats were divided into 3 groups: control, exposed to radiofrequency electromagnetic waves (RF-EMV), and exposed to RF-EMV during candesartan treatment. Spatial memory performance was assessed using the object recognition test and recognition memory performance using Morris water maze test. Significant differences where found between RF-EMV –exposed rats and RF-EMV –exposed rats treated with candesartan. Young Sprague-dawleyely rats were divided into three groups including the EMF- exposed group, 0.5mg/kg Candesartan treated during EMF exposure and control. Compared to control, EMF-exposed group impaired learning, spatial and short term memory along with unaffected sensorimotor function whereas Candesartan treated group improved learning, spatial memory and short term memory deficit induced by EMF in addition to absence of its effect on sensorimotor function. Although our data provides evidences of the protective effects of candesartan against RF-EMV-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.