Raw Data for the article by Fazullina ON et al.

Published: 10 October 2021| Version 1 | DOI: 10.17632/485vxf62nt.1
Contributors:
Anton Korbut,
,

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Osteoporosis and type 2 diabetes (T2) is widespread comorbidity leading to excess mortality and an enormous healthcare burden. In T2D, bone mineral density (BMD) may lead to an underestimation of the risk of low-energy fractures as bone quality is reduced. In this study, we assessed factors that affect the trabecular bone score (TBS), an indicator of bone quality/microarchitecture, in postmenopausal women with T2D. Sixty Caucasian women aged from 50 to 75 years with T2D duration of at least a year were included. Risk factors of secondary osteoporosis acted as exclusion criteria. BMD, TBS and body composition parameters were assessed by dual-energy X-ray absorptiometry. The serum levels of parathyroid hormone and 25-hydroxyvitamin D [25(ОН)D] were determined by ELISA. We found that TBS values of <1.31 were revealed in 29 women (48.3%). Age ≥64 years, diabetes duration ≥15 years, height ≥160 cm, body mass index <33 kg/m2, gynoid fat mass ≤5.5 kg, and android/gynoid fat mass ratio ≥1.15 were identified as the risk factors of the decreased TBS. In multiple logistic regression analysis, height, body weight, diabetes duration and haemoglobin A1c were associated with the trabecular bone score; in a model with body composition parameters, gynoid fat mass was a protective factor, while android fat mass was a risk factor of TBS decrease. In a model of multivariate stepwise regression analysis, age, fat mass and android/gynoid ratio demonstrated negative associations with the TBS, while body mass index was associated positively. In conclusion, in postmenopausal women with T2D and normal bone mineral density, age, diabetes duration, abdominal obesity, higher haemoglobin A1c and lower 25(OH)D levels are associated with trabecular bone score reduction.

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Naucno-issledovatel'skij institut kliniceskoj i eksperimental'noj limfologii

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