Under Normoxia Simvastatin Shifts Lipid Metabolism of B16.F10 Melanoma Cells to Support Their Aggressiveness
Description
Supplementary data to paper: "Under Normoxia Simvastatin Shifts Lipid Metabolism of B16.F10 Melanoma Cells to Support Their Aggressiveness" by Negrea et al., Biochemical Pharmacology, 2024. These data represents: 1) the Supplementary Table corresponding to all the mRNA identified by RNA-seq in B16.F10 melanoma cells treated with lipophilic statin simvastatin (SIM), compared to the untreated cells. Our data revealed a panel of 1513 out of 15905 transcripts with at least 1.5 FR in expression after SIM treatment, with 817 transcripts upregulated, and 696 downregulated compared to the control group; 2) Figure 1. Validation of primer specificity by agarose electrophoresis of PCR products and 3) Figure 2. Relative expression of genes involved in metabolic pathways assessed by RT-qPCR.
Files
Categories
Funding
UEFISCDI grant
PN-III-P2-2_1-PED-2021-0411, No. 659PED, 2022 granted to dr. Alina Sesarman
L'Oréal - UNESCO “For Women in Science"
Fellowship Programme no. 914, 2020 granted to dr. Alina Sesarman