Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial

Published: 5 October 2022| Version 1 | DOI: 10.17632/4pgkkd54n3.1
Kamilla La Haganes


Diet modification and exercise training are primary lifestyle strategies for obesity management, but poor adherence rates limit their effectiveness. Time-restricted eating (TRE) and high-intensity interval training (HIIT) improve cardiometabolic health in at-risk individuals, but whether these two interventions combined induce superior improvements in glycemic control than each individual intervention is not known. In this four-armed randomized controlled trial (ClinicalTrials.gov NCT04019860), we determined the isolated and combined effects of seven weeks of TRE (≤ 10-h ad libitum eating window every day) and HIIT (three exercise sessions per week), compared with a non-intervention control group, on glycemic control and secondary cardiometabolic outcomes in women with overweight/obesity. There were no statistically significant effects after isolated TRE, HIIT, or a combination (TREHIIT) on glucose area under the curve during an oral glucose tolerance test (the primary outcome) compared with the control group; TRE: -26.3 mmol/L, 95% confidence interval (CI): -82.3, 29.7 (p = .36), HIIT: -53.8 mmol/L, 95% CI: -109.2, 1.6 (p = .057), TREHIIT: -41.3 mmol/L, 95% CI: -96.4, 13.8 (p = .14). However, TREHIIT improved HbA1c and induced superior reductions in total and visceral fat mass compared with TRE and HIIT alone. High participant adherence rates suggest that TRE, HIIT, and a combination thereof, may be realistic diet-exercise strategies for improving markers of metabolic health in women at risk of cardiometabolic disease.



NTNU Institutt for sirkulasjon og bildediagnostikk


Exercise Physiology, Glucose Metabolism, Women's Health, Overweight, Diet, Lifestyle Intervention