Exhaled air profiling of cardiovascular patients by proton-transfer-reaction time-of-flight mass-spectrometry

Published: 28 October 2023| Version 1 | DOI: 10.17632/4ppwd9xmgh.1
Artemiy Silantyev,


We assume that the collected data contain valuable information about changes in the chemical composition of exhaled air associated with the development of such severe pathologies as coronary heart disease, myocardial infarction, hypertension. Published data include real-time breath analysis using PTR-TOF on 105 patients with cardiovascular pathologies (hypertension (N=88), coronary heart disease (N=39) and myocardial infarction (N=25)) and 104 controls were performed. Exhaled air was analyzed in real time using a highly sensitive real–time volatile organic compounds (VOCs) analyzer based on the proton transfer reaction - Ultra-Fast PTR-TOF 1000 mass spectrometry (Ionicon (Austria)). All data were collected from patients in the morning after brushing teeth without a special cleaner, for 1 minute and include approximately 12-16 respiratory cycles. The data was processed using the software Ionicon TOF 4.0, Python. Data includes raw PTR-TOF files; metadata includes demographic characteristics of patients and the results of clinical tests, such as biochemical blood analysis, full blood count and lipid profile.



Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova, Centr optiko-nejronnyh tehnologij NIISI RAN, Federal'noe mediko-biologicheskoe agenstvo


Omics, Pattern of Breathing, Cardiology


Ministry of Science and Higher Education of the Russian Federation