Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease

Published: 06-11-2020| Version 1 | DOI: 10.17632/4s3f4dv59g.1
Contributor:
gregoire chevalier

Description

Using human intestinal explants, we show that a specific FimH-blocker, TAK-018, inhibits bacterial adhesion to the intestinal epithelium and prevents inflammation, thus preserving mucosal integrity.

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