A Nonsynonymous Change in Adhesion G Protein–Coupled Receptor L3 Associated With Risk for Equine Degenerative Myeloencephalopathy in the Caspian Horse

Published: 9 October 2018| Version 1 | DOI: 10.17632/4vhd8btfkb.1
Contributor:
Samantha Brooks

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A Nonsynonymous Change in Adhesion G Protein–Coupled Receptor L3 Associated With Risk for Equine Degenerative Myeloencephalopathy in the Caspian Horse Christian J. Posbergh, Geoffrey E. Pollott, Teresa L. Southard, Thomas J. Divers, Samantha A. Brooks DOI: https://doi.org/10.1016/j.jevs.2018.08.010 Journal of Equine Veterinary Science, November 2018, Volume 70, Pages 96–100 This dataset comprises plink binary format files for unfiltered genotypes generated on the Illumina Equine SNP50 array and employed in the above publication to identify a region of the Equine Genome statistially associated with Equine Degenerative Myeloencephalopathy (EDM). In addition to genotypes from two cases of EDM produced for this work, 90 healthy adult horses of diverse breeds were included as controls from publicly available data sets, as published in these two papers: Makvandi-Nejad, S., Hoffman, G.E., Allen, J.J., Chu, E., Gu, E., Chandler, A.M. et al. Four loci explain 83% of size variation in the horse. PLoS One. 2012; 7: e39929 Petersen, J.L., Mickelson, J.R., Cothran, E.G., Andersson, L.S., Axelsson, J., Bailey, E. et al. Genetic diversity in the modern horse illustrated from genome-wide SNP data. PLoS One. 2013; 8: e54997 The edm_pheno.txt file contains two phenotype designations. "1" describes cases as a "2" and Caspian breed controls as a "1". Phenotype column "2" denotes the same two cases as "2", but marks all other horses in the set as controls with a phenotype of "1" The FID (first column) uses a three letter code to denote the horse breed as follows: AND Andalusian ARD Ardennais ARR Arabian BEL Belgian BEL Belgian BRB Brabant CLY Clydesdale CSP Caspian DMP Dartmoor Pony FLB Falabella FM Franches Montagnes FRE Friesian FT French Trotter HAN Hanoverian HOK Hokkaido ICE Icelandic MINI American Miniature MON Mongolian NORF Norwegian Fjord PER Percheron QH Quarter Horse SB Saddlebred SFP Suffolk Punch SHR Shire STBD Standardbred STP Shetland Pony SZWB Swiss Warmblood TB Thoroughbred WLP Welsh Pony WMP Welsh Mountain Pony

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Institutions

Cornell University, Royal Veterinary College

Categories

Equine Genetics

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