Data for: Sustainable Synthesis of N-Heterocycles in Water using Alcohols following the Double Dehydrogenation Strategy

Published: 31 March 2020| Version 1 | DOI: 10.17632/4xc9z48r9n.1
Contributor:
Sabuj Kundu

Description

The present study describes the synthesis of pharmaceutically relevant N-heterocycles like substituted quinolines, acridines and 1,8-naphthyridines in water under air using alcohols in presence of a new water soluble Ir-complex. The viability of this approach was demon-strated by the efficient synthesis of biologically active natural product (±)-galipinine and gram scale synthesis of various N-heteroaromatics. Kinetic experiments and DFT calculations suggested a concerted outer sphere mechanism for the dehydrogenation of alcohols.

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