Lactobacillus plantarum alleviates postmenopausal hypercholesterolemia by remodeling intestinal microbiota to increase secondary bile acids excretion
Published: 12 May 2023| Version 1 | DOI: 10.17632/5b3xz2gk5z.1
Contributor:
Shurui ZhangDescription
The experimental animal license number is SCXK(Zhe)2019-0001 andSCXK (Jing) 2019-0001 ,and the Experimental Animal Ethics number is202109A022. In this study.LP was used to treat the model of postmenopausal hypercholesterolemia . Our findings shed light on the mechanisms behind the lipid-lowering effects of LP, and suggest that reconstituting the intestinal microbiota to correct bile acid abnormalities may be a potential treatment for postmenopausal hypercholesterolemia. All statistical analyses were performed using GraphPad Prism 7.0(GraphPad Software Inc.), correlation analysis of the heat map at https://www.originlab.com/ and intestinal flora data analysis and drawing on https://www.genescloud.cn/home.
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Institutions
- Nanjing University of Chinese Medicine
Categories
Pharmacology, Bile Acid Metabolite, Gut Microbiota, Animal Age