Association between bullous pemphigoid and chronic kidney disease: A bidirectional Mendelian randomization study

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Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Increasing evidence showed BP is associated with systemic diseases, however, researches about BP and chronic kidney disease (CKD) are limited. Although a cohort study found individuals with CKD had increased risk of BP, 1 there has been no genetic evidence to demonstrate the casuality between BP and CKD. Mendelian Randomization (MR), based on genome-wide association studies (GWAS), is a method for determining causality between potentially modifiable risk factors and health outcomes. Here, we employed a bidirectional MR analysis to identify the association between BP and CKD.

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