Data for: Which is the best use for tranexamic acid on patients with thoracolumbar fracture, topical, intravenous or combined? A randomized controlled clinical trial.
This was a randomized controlled clinical trial that Investigated 181 patients with thoracolumbar fracture who were treated with percutaneous pedicle screw fixation. These patients were randomly divided into three groups: group A (30 mins preoperative intravenous TXA 15 mg/kg and postoperative topical application with 3g normal saline), group B (30 mins preoperative intravenous normal saline 15 mg/kg and postoperative topical application with 3g TXA), group C (30 mins preoperative intravenous TXA 15 mg/kg and postoperative topical application with 3g TXA). The total blood loss(TBL), hidden blood loss(HBL), intraoperative blood loss(IBL), Preoperative d-dimer, postoperative d-dimer, incidence of deep vein thrombosis (DVT) and other complications were compared and analyzed between the three groups.