Data for: The peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates of different morphology

Published: 31 March 2020| Version 1 | DOI: 10.17632/5jhk5c5xk9.1
Contributors:
Olga Golubeva,
Yulia Alikina,
Elena Brazovskaya,
Valery Ugolkov

Description

The peculiarities of an anticancer drug 5-fluorourocil adsorption by aluminosilicate matrices of different morphology — BEA zeolites, layered silicates with saponite (Mg3Si4O10(OH)2.H2O) and montmorillonite (Na0.2Al1.8Mg0.2Si4O10(OH)2.H2O) structures, nanotubular halloysite (Al2Si2O5(OH)4.2H2O) were investigated. The influence of the polarity of the solvent used (water, acetone, ethanol), the pH-environment (pH=5, 8, 11), the morphology (framed, layered and nanotubular) and chemical composition (Al2O3 content 0-40 wt.%) of the initial matrix on the amount of the adsorbed drug was studied. In order to prevent errors associated with the possibility of the existence of various tautomeric forms of fluorouracil in solutions, studies of the adsorption processes were carried out exclusively using thermal analysis coupled with mass spectrometry. It has been established that the efficiency of 5-fluorourocyl adsorption and the loading conditions are largely determined by the chemical composition of the initial aluminosilicate matrix and its morphology. The highest adsorption capacity for fluorouracil in any conditions of saturation is characteristic for zeolite, and the smallest - for halloysite matrix.

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