Presence of microscopic vascular invasion is not associated with overall or recurrent-free survival in patients with solitary hepatocellular carcinoma ≤ 2 cm who underwent liver resection
Description
Purpose: To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liver resection (LR). Methods: This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary HCC of ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. Results: Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5–70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. Conclusion: The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort.
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The data used were extracted from the Kaohsiung Chang Gung Memorial Hospital HCC registry database. The data in the database were prospectively collected. We checked the vital statuses of the patients annually in the database using the Cancers Screening and Tracing Information Integrated System for Taiwan (https://hosplab.hpa.gov.tw/CSTIIS/index.aspx).