Genome-wide convergent analyses and transgenic evidence reveal a single origin of laryngeal echolocation in bats
We hypothesized that if the echolocation of bats originated in the ancestor of all bats, more convergent sites in hearing-related genes will be observed between dolphin and the ancestral lineage of all bats and these substitutions might affect the function of hearing-related genes. We used comparative genomics and functional experiments to test these hypotheses!
Steps to reproduce
11145 one-to-one orthologous genes across 27 mammals extracted from the OrthoMaM database (v10b), including 104 hearing-related genes according to Gene Ontology Biological Process (GO:0007605 sensory perception of sound) and the prestin sequences of 40 mammals used to infer the ancestral sequences in the internal nodes of bats. The detailed information can be seen from our paper, which is under review in Current Biology.