Single-Cell and Spatial Multi-Omics in Immune-Mediated Hair Disorders: Supplementary Material

Description

Supplementary material for a scoping review submitted to JAAD Reviews. Contains: Supplementary Methods (full search strategy, eligibility criteria, data charting); Supplementary Results (detailed thematic analysis of 18 studies); Supplementary Discussion; Supplementary Table 1 (characteristics of included studies, n=18); Supplementary Table 2 (computational methods inventory); Supplementary Figures 1–5; and Supplementary References 1–28.

Steps to reproduce

Scoping review following PRISMA-ScR guidelines. Systematic search of PubMed/MEDLINE, Embase (via Ovid), Web of Science Core Collection, and bioRxiv/medRxiv from inception through February 2026. Search combined technology terms (scRNA-seq, scATAC-seq, spatial transcriptomics, Visium, MERFISH, GeoMx) with disease/tissue terms (hair follicle, alopecia areata, cicatricial alopecia, androgenetic alopecia, scalp). From 387 identified records, 298 were screened after duplicate removal, 44 underwent full-text review, and 18 studies were included. Data extraction used a standardized charting form. Narrative thematic synthesis across four domains: immune cell landscapes, spatial niche mapping, computational methodology, and translational target discovery.

Institutions

• National Taiwan University Hospital

  Taiwan, Taipei

Categories

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