Database of Animal Systematic Review Publications

Published: 10 February 2021| Version 1 | DOI: 10.17632/6fr3nw5mpc.1
Carlijn Hooijmans,
Miranda Langendam,
Andrew Rooney,
Vickie Walker,
Kembra Howdeshell,
Michelle Cawley,
Kristen Magnuson,
Ashley R. Williams ,
Alice Tillema,
Joshua Cleland,
Christopher Stevens,
George Agyeman-Badu,
Carlye Austin,
Marc Avey,
Steven Black,
Kathleen Clark,
Jon Davis,
Lindsey Green,
Angela Hensel,
Melinda Hoang,
Kendra Jobe,
Gillian Laidlaw,
Jessica Levasseur,
Camryn Lieb,
Alexander Lindahl,
Rachel McGill,
Devon Morgan,
Revathi Muralidharan,
Alicia Murphy,
Cara Peyser,
Delaney Reilly,
Amanda Ross,
Alessandria Schumacher,
Codi Sharp,
Robert Shin,
Catherine Smith,
Samantha Snow,
Parnian Soleymani,
River Williams


This database compiles systematic reviews (SRs) of animal studies (i.e., reviews that focused exclusively on non-human animal research, or reviews that included animal studies along with human studies). This database was developed using a rigorous, systematic approach and it covers a broad range of research fields: preclinical research, toxicology, environmental health, and veterinary medicine. The goals of this database are to: (1) provide a comprehensive collection of animal study SRs to advance systematic review methods development; (2) enable researchers to avoid duplication of effort and, thus, reduce research waste by identifying published SRs of animal studies that may already address a research question; and (3) aid in the creation of evidence maps, usually designed as interactive figures of study characteristics. The SRs included in the database were identified using a comprehensive search strategy (see data) in MEDLINE (via PubMed), Embase (via Ovid), and Web of Science. The records included in the animal studies SR database meet the following eligibility criteria: 1. The reference aims to systematically review the literature. The title or abstract states this aim using terminology such as “literature review,” “literature overview,” “systematic review,” “systematic survey,” or “meta-analysis.” 2. The reference summarizes the results of studies in laboratory or experimental animals to investigate human or animal health. 3. The reference reports the eligibility criteria for the primary studies, specifies search terms, and the search is performed in at least one specified database/electronic source (e.g., PubMed). 4. A full text version of the reference is publicly available. There were no restrictions in language or publication date. Version 1.0 covers data through 13 February 2018 Version 1.1 covers data through 18 June 2019


Steps to reproduce

Update the search by using the comprehensive search strategy provided for MEDLINE (via PubMed), Embase (via Ovid), and Web of Science. - Remove all references previously screened (use most recent reference library provided) - Screen all references. Studies were included, unless they met one or more of the following exclusion criteria: 1) aim of the paper was not a systematic review, 2) paper did not include laboratory animals, 3) paper did not state the eligibility criteria for primary studies, 4) paper did not specify what sources (e.g., databases) were searched, 5) paper did not specify the search terms used in the search, or the 6) full-text paper could not be retrieved. In the case that it was unclear whether a reference was an SR that included animal studies, the reference was included in the database. - Extract all data elements ( author, publication year, title, abstract, citation, total number of sources (e.g., databases) searched, names of sources searched, performance of meta-analysis (yes/no), and use of study quality assessment (yes/no)) and enter them into the Microsoft Access database (Redmond, WA).


Radboudumc, National Institute of Environmental Health Sciences National Toxicology Program Division


Toxicology, Veterinary Medicine, Environmental Health, Meta-Analysis, Systematic Review, Preclinical Study