These data is the supplementary material of a paper accepted for publication in The Journal of The American Academy of Dermatology, entitled “Risk of systemic infections in adults with atopic dermatitis: a nationwide cohort study.” by Catherine Droitcourt et al. The objective of this nationwide registry-based study was to examine whether adults with AD had increased risk of systemic infections compared to adults from the general population. The design is a cohort study. Hazard ratios (HR) with 95% confidence intervals (CI) were estimated using Cox models. These data include additional details on material and methods (identification of the covariates and definition of categories of atopic dermatitis severity); the list of International Classification of Diseases, version 10 (ICD-10) codes used to identify the systemic infections and the general comorbidities with the Charlson comorbidity index; the results of stratified analyses according to gender, age group (18 to 39 years and over 39 years), use of systemic corticosteroid (yes/no) and atopic dermatitis severity; and the result of sensitivity analyses (one including only systemic infections which leads to hospitalization (>24 hours) and one including possible hospital-acquired systemic infections defined by hospital secondary diagnoses).