Dataset for Small Integrin Binding Ligand N-linked Glycoproteins, prostate-specific antigen and time to prostate cancer diagnosis.

Description

Data are from a retrospective longitudinal case control study that was performed to determine the association of the SIBLINGs Dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), osteopontin (OPN) and prostate-specific antigen (PSA) with preclinical prostate cancer. Paired serum samples from 109 cancer-free Baltimore Longitudinal Study on Aging participants were divided into those that were either most distal or proximal to diagnosis (cases) or censoring (controls). DSPP, BSP, OPN, and PSA were measured by immunoassay and dichotomized into low or high based on their respective cut-off values. Associations of individual biomarkers and aggregated biomarkers with time to diagnosis or death, modeled as disease-free survival or overall survival, were assessed using Kaplan Meier to assess survival curves graphically and median survival estimates in distal or proximal sets separately. Cox proportional hazard survival hazard ratios were determined for individual and aggregated biomarkers in distal or proximal sets separately, Models were adjusted for age, BMI and hypertension and the significance of the hazard ratios was assessed by false discovery rate analysis.

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