Differential Gene Expression Data from the Human Central Nervous System across Alzheimer’s Disease, Lewy Body Diseases, and the Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Spectrum

Published: 14 January 2021| Version 2 | DOI: 10.17632/752nd4w7pd.2
Contributors:
,
Aziz M. Mezlini,
Bradley T. Hyman,
,

Description

In Noori et al. (2020), we hypothesized that there is a shared gene expression signature underlying neurodegenerative proteinopathies including Alzheimer’s disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum. To test this hypothesis, we performed a systematic review and meta-analysis of 60 human central nervous system transcriptomic datasets in the public Gene Expression Omnibus and ArrayExpress repositories, comprising a total of 2,600 AD, LBD, and ALS-FTD patients and age-matched controls which passed our stringent quality control. Here, we provide the results of differential expression analyses with data quality reports for each of these 60 datasets. This atlas of differential expression across AD, LBD, and ALS-FTD may guide future work to elucidate the pathophysiological drivers of these individual diseases as well as the common substrate of neurodegeneration.

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Steps to reproduce

Source code is available on GitHub: https://github.com/ayushnoori/nd-diff-expr.

Institutions

Harvard College, Harvard Medical School, Massachusetts General Hospital

Categories

Neuroscience, Life Sciences, Bioinformatics, Transcriptomics

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