B-Raf inhibitor counteracts sulfur mustard-induced epidermal impairment

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These data show that i) vemurafenib displays apparent protective effects on HaCaT cells and resisted SM toxicity on HaCaT cells upon SM exposure, including cell survival, intracellular ATP level, apoptosis, and proinflammation cytokine IL-6 production; ii) the cell protective effect of vemurafenib during SM injury is ERK-dependent; iii) vemurafenib improves cutaneous damage on the mouse ear vesicant model.

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