Sequential activity of CA1 hippocampal cells constitutes a temporal memory map for associative learning in mice
Description
Sequential neural dynamics encoded by “time cells” play a crucial role in hippocampal function. However, the role of hippocampal sequential neural dynamics in associative learning is an open question. We used two-photon Ca2+ imaging of dorsal CA1 (dCA1) neurons in the stratum pyramidale (SP) in head-fixed mice performing a go-no-go associative learning task to investigate how odor valence is temporally encoded in this area of the brain. We found that SP cells responded differentially to the rewarded or unrewarded odor. The stimuli were decoded accurately from the activity of the neuronal ensemble, and accuracy increased substantially as the animal learned to differentiate the stimuli. Decoding the stimulus from individual SP cells responding differentially revealed that decision-making took place at discrete times after stimulus presentation. Lick prediction decoded from the ensemble activity of cells in dCA1 correlated linearly with lick behavior indicating that sequential activity of SP cells in dCA1 constitutes a temporal memory map used for decision-making in associative learning. Here we deposit the data necessary to generate the figures in our Current Biology manuscript (DOI: 10.1101/2023.10.01.560382) using the code deposited in https://github.com/restrepd/CA1_Figures
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National Institutes of Health
DC000566
National Institutes of Health
NS116241
Division of Behavioral and Cognitive Sciences
1926676