Cerebellar Damage from Brainstem Tumors and Impacts on Behavioral Disorders in Children
Description
The follow tables are information and the segmented lobular volume of the cerebellar of 996 participants.
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We collected MRI images from Beijing Tiantan Hospital. Structural MRI scans were performed using a 3.0 T scanner (Ingenia CX, Philips Healthcare) with a 32-channel head receiver coil. The 3D T1-weighted sequence consisted of 196 contiguous sagittal slices with a voxel size of 1.0 x 1.0 x 1.0 mm³. Specific parameters were: TR = 6.572 ms; TE = 3.025 ms; FA = 8°; slice thickness = 1 mm; in-plane resolution = 1x1 mm. DICOM images were converted to NIFTI format. The typical radiological characteristics are presented in Fig. 2. To ensure accurate segmentation and avoid misclassifying the brainstem as the cerebellum, neurosurgeons delineated the brainstem as the volume of interest (VOI) using MRIcroGL. Automatic segmentation of cerebellar lobules was performed using ACAPULCO software (version 0.2.1) with a pediatric template16. Segmentation accuracy was visually inspected by two researchers, with manual corrections made using ITK-SNAP. We obtained volumes for 28 distinct cerebellar regions, including left and right lobules I-III, IV, V, VI, VIIB, VIIIA, VIIIB, IX, X, Crus I, Crus II, and vermis lobules VI, VII, VIII, IX, X, and corpus medullare. To address the non-uniform margin between lobules VIIIA and VIIIB, they were combined into a single lobule, designated as lobule VIII. Thus, 26 independent cerebellar region volumes were used to analyze individualized cerebellar changes and their associations with behavioral outcomes.