Assessment of a New Volumetric Capnography-derived Parameter to Reflect Compression Depth and to Predict Return of Spontaneous Circulation during Cardiopulmonary Resuscitation in a Porcine Model

Published: 19-03-2020| Version 3 | DOI: 10.17632/7p27nk75k3.3
Lili Zhang


This experimental cross-over study using a domestic pig model evaluated a volumetric capnography-derived parameter, the volume of CO2 eliminated per minute and per kg body weight (V’CO2kg-1), as an indicator of quality of chest compression (CC) and as a predictor of return of spontaneous circulation (ROSC) under stable ventilation status following cardiac arrest. Animals were subjected to untreated ventricular fibrillation, followed by mechanical cardiopulmonary resuscitation (CPR) and ventilation. Three types of CC quality were tested, followed by advanced life support, consecutively. We believe that our study makes a significant contribution to the literature because we showed that CC quality had a significant effect on the partial pressure of end-tidal carbon dioxide (PETCO2), V’CO2kg-1, and other hemodynamic variables. While, V’CO2 kg-1 had similar performance as PETCO2 in terms of CC quality and ability to predict to ROSC, V’CO2kg-1 requires a longer time to achieve a stable state.