Supplementary data for hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing

Name: Supplementary data for hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing
Creator: Rong Zheng
Published: 2024-05-30T08:36:02.773Z
Keywords: Cancer, RNA Splicing, Interferon Type I, Double-Stranded RNA

Zheng, Rong; Dunlap, Mikayla; Bobkov, Georg O.M.; Gonzalez-Figueroa, Carlos; Patel, Khushali J.; Lyu, Jingyi; Harvey, Samuel E.; Chan, Tracey W.; Quinones-Valdez, Giovanni; Choudhury, Mudra; Le Roux, Charlotte A.; Bartels, Mason D.; Vuong, Amy; Flynn, Ryan A.; Chang, Howard Y.; Van Nostrand, Eric L.; Xiao, Xinshu; Cheng, Chonghui

doi:10.17632/7p7dpzcc6x.1

Supplementary data for hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing

Published: 30 May 2024| Version 1 | DOI: 10.17632/7p7dpzcc6x.1

Contributors:

Rong Zheng, Mikayla Dunlap, Georg O.M. Bobkov, Carlos Gonzalez-Figueroa, Khushali J. Patel, Jingyi Lyu, Samuel E. Harvey, Tracey W. Chan, Giovanni Quinones-Valdez, Mudra Choudhury, Charlotte A. Le Roux, Mason D. Bartels, Amy Vuong, Ryan A. Flynn, Howard Y. Chang, Eric L. Van Nostrand, Xinshu Xiao, Chonghui Cheng

Description

This study shows that depletion of hnRNPM results in global cryptic splicing. hnRNPM-repressed cryptic exons are enriched in LINE elements and can generate long stem-like double stranded RNAs (dsRNAs), which in turn stimulate antiviral signaling, elevate tumor immune infiltration, and improve cancer patient survival. Excel file contains unprocessed images from Western Blot and agarose gels.

Supplementary data for hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing

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