Epidural 0.125% ropivacaine is safe but insufficient for induced tibiotarsal joint pain

Description

This data set is available for "Epidural 0.125% ropivacaine is safe but insufficient for induced tibiotarsal joint pain" (accepted to Equine Veterinary Journal)

Steps to reproduce

Methods Eight healthy, sound horses underwent two treatments in random order, separated by at least 3 weeks: epidural saline or epidural ropivacaine. For each treatment, an epidural catheter was inserted at the first intercoccygeal space and advanced 5 cm cranially. Correct catheter placement was confirmed radiographically after injecting contrast through it. The tibiotarsal joint was injected with 75 ng of recombinant equine interleukin‐1β to induce synovitis. Twelve hours later, baseline variables were recorded, including heart rate, respiratory rate, borborygmi, lameness score and neurological examination score. Thirty minutes thereafter [time = 0 h (t0)], 0.045 mL/kg of preservative‐free 0.9% saline or 0.125% ropivacaine was administered through the catheter over 10 min. Data were collected at t0.5, 1, 1.5, 2.5, 3.5, 4.5, 5.5, and 6.5. Faecal piles passed the 24 h before and after t0 were counted. Continuous and categorical data were analysed using a linear mixed effects model and Fisher's exact test, respectively, with significance set at p < 0.05.

Institutions

• Cornell University

  New York, Ithaca

Categories

Funders

• Harry M Zweig Memorial Fund for Equine Research

Licence