Evoked intracranial potentials in patients with epilepsy

Published: 31 October 2019| Version 1 | DOI: 10.17632/7v2vcc9v28.1
Contributors:
Bornali Kundu,
Tyler Davis,
Brian Philip,
Elliot Smith,
John Rolston

Description

The parameters affecting the evoked response in the brain as a result of brain stimulation is not well understood. Yet it is widely used in research and clinical settings (e.g. responsive neurostimulation to treat intractable multifocal epilepsy in humans). In an effort to better understand the parameters that affect the response to brain stimulation, single pulse electrical stimulation was delivered to different brain regions of patients with epilepsy undergoing long term monitoring. These data were recorded off depth and surface cortical electrodes. These are the summarized trial data derived from patients. 11 patients are included in this data set. The data are organized into a MATLAB variable type table and saved in .mat form. These data were recorded, epoched, filtered, and processed as described in the submitted manuscript "A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy" by authors Bornali Kundu, Tyler S. Davis, Brian Philip, Elliot H. Smith, Amir Arain, Angela Peters, Blake Newman, Christopher R. Butson and John D. Rolston. The columns of the table consistent of the following variables: (1) patientnum - the patient ID number (2) stimlevel - the stimulation level delivered, in microvolts (3) stimchan - the number ID of the stimulation channel (4) respchan - the number ID of the response channel from which the evoked response was measured (5) isdpth - 1 = the channel was from a depth electrode, 0 = the channel was from a cortical surface electrode (6) distance - distance between the stimulation channel and response channel in Euclidian space, in mm (7) issozstim - 1= the stimulation channel was located in the clinical SOZ, boolean variable (8) issozrep - 1= the response channel was located in the clinical SOZ, boolean variable (9) posthgpwr100 - raw trial power after bandpass filtering the epoched data from 70-150Hz, calculating the Hilbert transform of the data, and then calculating the mean from 5 - 100ms as described in the methods section, data are log transformed (10) postrawmav100 - raw voltage data mean from 5-100 ms for the trial, in milivolts, data are log transformed (11) trials - trial number ID (12) regionstim - the region of the stimulation channel determined from an atlas as described in the methods (13) regionresp - the region of the response channel determined from an atlas as described in the methods (14) issoz - boolean variable, true corresponds to if the stimulation channel, response channel, or both were in the clinical SOZ (15) regionresptype - categorical description of the region of the response channel (16) regionstimtype - categorical description of the region of the stimulation channel Funding: JDR is supported by the NIH, NCATS KL2 TR002539and NINDS R21 NS113031. BK is supported in part by a NREF neurosurgical research grant.

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