Supplementary Data for the Huobahuagen–Finerenone Study in Diabetic Kidney Disease

Description

This dataset contains nine supplementary tables (S1–S9) supporting the study entitled "Network Pharmacology and Transcriptomics Prioritize Candidate Targets and Metabolic Pathways for the Huobahuagen-Finerenone Combination in DKD." Tables S1–S5 provide candidate target gene annotations, eQTL dataset identifiers, Mendelian randomization (MR) screening status, complete MR estimates, heterogeneity and horizontal pleiotropy analyses, and SNP-level instrumental variable information. Tables S6–S9 provide single-cell RNA-sequencing results, including cluster-specific marker genes, sample-level comparisons of DPP4, CA2, and SLC12A3 expression across renal cell types, distal convoluted tubule marker expression, and cell counts by sample and annotated cell type. The analyses were based on publicly available data from GEO (GSE209781) and IEU OpenGWAS. The deposited Excel workbook provides supplementary analytical results to support the findings reported in the associated manuscript.

Steps to reproduce

The supplementary tables were generated from Mendelian randomization and single-cell RNA-sequencing analyses using publicly available datasets from IEU OpenGWAS and GEO (GSE209781). Detailed analytical methods, software, and parameters are described in the associated manuscript.

Institutions

• Shanxi Medical University

  Shanxi, Taiyuan

Categories

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