In-situ synthesis of ultrasmall ZnCoS nanoparticles on bimetallic metal-organic framework for enhanced electrochemical sensing of dopamine

Published: 8 May 2026| Version 1 | DOI: 10.17632/7wnx887mgv.1
Contributor:
xiaoli liu

Description

Abstract Integrating bimetallic sulfides into metal-organic frameworks (MOFs) crystal materials to develop MOF-based composites was an effective strategy to enhance the electrochemical performance of MOFs. Herein, bimetallic MOF zinc/cobalt-porphyrin (ZnCo-TCPP) nanosheets were firstly prepared using a facile surfactant-assisted method, and then ZnCoS/ZnCo-TCPP was synthesized by in-situ sulfidation of ZnCo-TCPP with thioacetamide (TAA) under different vulcanization times. Subsequently, a novel dopamine (DA) sensing method was established based on these materials. The morphologies, compositions and structures of these compounds were characterized by Transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and N2 adsorption/desorption isotherm. The characterization results indicated that ZnCoS with a size of about 5 nm were uniformly dispersed on the surface of ZnCo-TCPP without agglomeration. The electrochemical results demonstrated that ZnCoS/ZnCo-TCPP had the highest current response to DA oxidation with the vulcanization time of 3 h. The linear range of the sensor based on ZnCoS/ZnCo-TCPP was 0.01-327.8 μM, the detection limit was determined to be 3 nM (S/N＝3), and the sensitivity was 379.3 μA mM−1 cm−2. Compared with analogous types DA sensors reported in previous literature, the linear range of this sensor had been expanded by at least an order of magnitude, and the detection limit had been reduced by at least an order of magnitude. Furthermore, the fabricated sensor was used to detect DA in human serum with the recoveries ranged from 96.26% to 103.6%. The acceptable recoveries rate proved that the sensor had the potential for the efficient determination of DA. The proposed strategy provided a discriminative and sensitive analytical platform for DA clinical diagnostics and drug screening. Keywords: Electrochemical sensing, Bimetallic MOF, Bimetallic sulfides, Dopamine.

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Categories

Analytical Chemistry, Electrochemical Sensing

Funders

  • National Natural Science Foundation of China
    Beijing
    Grant ID: No. 21575113
  • Xi’ an Natural Science Foundation
    Grant ID: (No. 24GXFW0081-05)
  • Xi’ an University of Arts and Science Undergraduate Innovation and Entrepreneurship Training Program
    Grant ID: No. DC2026040

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