Patients were selected by simple randomization following the order of arrivals in two different groups of treatment (1st line) Group 1 (OAC-10): amoxicillin 1 g twice daily + omeprazole 20 mg twice daily + clarithromycin 500 mg twice daily for 10 days. Group 2 (OAC-14): amoxicillin 1 g twice daily + omeprazole 20 mg twice daily + clarithromycin 500 mg twice daily during 14 days. For the second line (failure of 1st line) , two others protocols were evaluated, OAC-10 regimen+ Levofloxacin (OAC-10+) and the bismuth-based therapy during 10 days. The OAC-10+ protocol consisted to the addition of Levofloxacin 500 mg once daily while bismuth-based therapy included Pantoprazole 20 mg twice daily + bismuth salt 140 mg four times daily + metronidazole 125 mg four times daily+ tetracycline 125 mg four times daily for ten days. Our primary endpoint was H. pylori eradication (HP Ag2 or HP Ag3 for the second line) and secondarily, the compliance and adverse effects. Adverse effects were self-reported by patients and ingesting more than 90% of the regimen full dose is good compliance.