Supplemental data for: Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs. Wünsche et al., 2018
Description
GWAS SNP data accompanying Wünsche et al., 2018: In total 33,044 GWAS SNPs were downloaded from the NHGRI-EBI Catalog of published genome wide association studies (https://www.ebi.ac.uk/gwas/) as “All associations v1.0”. Next, GWAS SNPs from non European studies as well as chromosomal translocations and abnormalities were filtered out in order to match the genetic background of the patients with the data, yielding 24,434 remaining GWAS SNPs. Furthermore, GWAS SNPs were manually classified into 17 categories, adapted from Maurano et al. (2012) and Mifsud et al. (2015). For more information please refere to the supplements (STAR-Methods). Unprocessed integration site data accompanying Wünsche et al., 2018: The Excel file contains IS from all 10 patients. The first 6 colums depict the chromosome (Chrom), IS orientation (Sense), the exact location (Loc), closest Gene (Gene), the total number the sequence was found (Total # IS Sequences Found) and the total number how often this IS was sequenced in different samples (Total # ISs Found). The following colums describe the samples (dayXXXtissue) with total number of IS detected in this sample and the total number of IS sequences per sample (nCh = after chemotherapy). A number in the column of a sample refers to the location on the left and resembles the percent of reads this IS had compared to all reads for this sample. For more information on how these data were generated, please refere to the supplements (STAR-Methods).