Differences in diffusion weighted imaging and resting-state functional connectivity between two culturally distinct populations of prairie vole

Published: 30 October 2020| Version 1 | DOI: 10.17632/85vd7w525n.1
Contributors:
Richard J Ortiz,
Jason R Yee,
Praveen Kulkarni,
Nancy Solomon,
Brain Keane,
Xuezhu Cai,
Craig Ferris,
Bruce Cushing

Description

We used the highly prosocial prairie vole to test the hypothesis that higher-order brain structure, microarchitecture and functional connectivity, would differ between males from populations with distinctly different levels of prosocial behavior. Specifically, Males from Illinois (IL), who display high levels of prosocial behavior and F1 males from Kansas dams and Illinois males (KI), which display the lowest level of prosocial behavior and higher aggression. Behavioral differences between these males are associated with overexpression estrogen receptor alpha in the medial amygdala (MeA) and bed nucleus of the stria-terminalis (BST) and neuropeptide expression in the paraventricular nucleus (PVN). We compared apparent diffusion coefficient (ADC), fractional anisotropy (FA), and BOLD resting-state functional connectivity (rsFC) between males. The article is published in 'Biological Psychiatry: Cognitive Neuroscience and Neuroimaging' with DOI: /10.1016/j.bpsc.2020.08.014 Fc-Conn Data: The Functional Connectivity data is in "FcConnData.zip" folder. Once unzipped into 'FcConnData' folder it has two subfolders for 'IL' for Males from Illinois and ''KSIL" males from Kansas dams and Illinois males. Inside these folders there are separate folder for each subject (Vole). This subject folder contains the EPI Fc-Conn data in NIFTI (.nii) format along with mask and cropped file. The filenames of these files is self explanatory. The processing steps are explained in detail in article. DTI Data: The DW-3D-EPI images were processed and analyzed using MATLAB (Mathworks, Natick, MA) and MedINRIA (version 1.9.0; http://www-sop.inria.fr/asclepios/software/MedINRIA/) software. This data is in "DTI_data.zip" file. Once unzipped into DTI_data folder, this has two subfolders 'IL' for Males from Illinois and ''KSIL" males from Kansas dams and Illinois males. All DWI raw data was converted from bruker format to img/hdr (Analyze) format via MATLAB and stored in individual folder (#_B900). The reserve folder contains the following computed images: ADC, FA, L1, L2, L3 and RD along with B0 image. Each of the extracted image files contains a ROI .nii file and a result excel sheet.

Files

Steps to reproduce

The published article explains in detail the data processing steps for DWI as well as Fc-Connectivity.