Published: 30 December 2016| Version 1 | DOI: 10.17632/86xgvsd7zh.1
J Bertran-Gonzalez,
Miriam Matamales


\Data type and description: event-time stamp data. The time at which each event occurred (Y matrix, values 1-4) was stamped with a 10 ms resolution (Z matrix, centiseconds). Y matrix: 1=active response; 2=inactive response; 3=delivered pellet; 4=Magazine entry (time-controlled; consecutive entries within 200ms are not repeatedly stamped). Data were obtained through MED STATE NOTATION (MED Associates)


Steps to reproduce

\Experiment summary: 7 dSPN-hM4Di(-) (WTp221, 222, 204, 223, 205, 207, 226) and 7 dSPN-hMDi(+) (Cre224, 206, 208, 209, 211, 225, 227) littermate mice (C57Bl6) were allowed to recover from surgery (3 weeks) prior to being exposed to instrumental training (increasing random ratio schedule of reinfocement). CRF days 1-3): constant reinforcement; RR5 (days 4-7): random ratio 5; RR10 (days 8-9): random ratio 10; RR20 (days 10-17): random ratio 20. Active lever counterbalanced (Left [L] or Right [R]). \Penalising regime: from day 10 of training, a penalising protocol was introduced (pen5). From day 13, this regime was increased to pen7. Pen5: If the last 5 actions are not LP, probability of reward delivery is reseted; Pen7: If the last 7 actions are not LP, probability of reward delivery is reseted. \CNO treatment: from day 10, all mice were injected with Clozapine N-oxyde (3 mg/kg, i.p.) 45 min before the start of each session. \NOTE: Subject Cre207 was shifted of one day until Day 7. On day 7 it was run twice to catch up with the group.


The University of Queensland Queensland Brain Institute, University of New South Wales


Pharmacogenetics, Neural Pathway, Basal Ganglia, Operant Conditioning, Action Learning, Sequence Learning