Published: 30-12-2016| Version 1 | DOI: 10.17632/86xgvsd7zh.1
J Bertran-Gonzalez,
Miriam Matamales


\Data type and description: event-time stamp data. The time at which each event occurred (Y matrix, values 1-4) was stamped with a 10 ms resolution (Z matrix, centiseconds). Y matrix: 1=active response; 2=inactive response; 3=delivered pellet; 4=Magazine entry (time-controlled; consecutive entries within 200ms are not repeatedly stamped). Data were obtained through MED STATE NOTATION (MED Associates)


Steps to reproduce

\Experiment summary: 7 dSPN-hM4Di(-) (WTp221, 222, 204, 223, 205, 207, 226) and 7 dSPN-hMDi(+) (Cre224, 206, 208, 209, 211, 225, 227) littermate mice (C57Bl6) were allowed to recover from surgery (3 weeks) prior to being exposed to instrumental training (increasing random ratio schedule of reinfocement). CRF days 1-3): constant reinforcement; RR5 (days 4-7): random ratio 5; RR10 (days 8-9): random ratio 10; RR20 (days 10-17): random ratio 20. Active lever counterbalanced (Left [L] or Right [R]). \Penalising regime: from day 10 of training, a penalising protocol was introduced (pen5). From day 13, this regime was increased to pen7. Pen5: If the last 5 actions are not LP, probability of reward delivery is reseted; Pen7: If the last 7 actions are not LP, probability of reward delivery is reseted. \CNO treatment: from day 10, all mice were injected with Clozapine N-oxyde (3 mg/kg, i.p.) 45 min before the start of each session. \NOTE: Subject Cre207 was shifted of one day until Day 7. On day 7 it was run twice to catch up with the group.