An updated skin permeation database of compounds applied as aqueous solutions in in vitro

Published: 31 March 2022| Version 1 | DOI: 10.17632/8bs7hb2wj2.1


The database represented in this article is referred to by the review article entitled “Topical drug delivery: history, percutaneous absorption and product development” (MS Roberts et al., 2021) and also as a supplementary table for the article entitled "An updated dataset of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics and other solutes applied as aqueous solutions" (HS Cheruvu et al., 2022). This database contains maximal flux (Jmax), and permeability coefficient (kp) values collated from In Vitro human skin Permeation Test (IVPT) reports published to date for various drugs, xenobiotics and other solutes applied to human epidermis from aqueous solutions. Also included are each solute’s physicochemical properties and the experimental conditions, such as temperature, skin thickness, and skin integrity, under which the data was generated. This database is limited to diluted or saturated aqueous solutions of solutes applied on human epidermal membranes or isolated stratum corneum in large volumes so that there was minimal change in the donor phase concentration. It can be used for establishing the The data may also be useful in developing new QSPRs that may aid in: (1) drug choice and (2) product design for both topical and transdermal delivery, as well as (3) characterising the potential skin exposure of hazardous substances.


Steps to reproduce

Collected all the published reports in literature (Google, Google Scholar, PubMed, Sci-Hub) related to in vitro human skin permeation of compounds from aqueous solutions dating from 1970's to 2021. From these reports, the experimental permeability values and corresponding compound physicochemical properties from PubChem, Chemspider, Drugbank, Chemical bookwere extracted and tabulated.


University of Queensland Faculty of Medicine and Biomedical Sciences


Skin, Permeability, Stratum Corneum, Human, Absorption Barrier, In Vitro Techniques