LANCE trial

Published: 15 December 2023| Version 1 | DOI: 10.17632/8dh8bv7kn5.1
Georgios Evangelou


The Lance study focuses on evaluating the impact of adding atezolizumab to chemotherapy in terms of survival benefits and progression-free survival. The study also investigates whether the biomarkers miR375 and miR21 have predictive value. Research Hypothesis: The hypothesis posits that atezolizumab, when combined with chemotherapy, improves overall survival and progression-free survival in patients. Additionally, it hypothesizes that miR375 and miR21 can serve as predictive biomarkers for treatment response. Data Collection and Methodology: Participants: The study involved patients receiving chemotherapy for a specific condition (not mentioned in the prompt). Intervention: Participants were divided into two groups; one receiving standard chemotherapy and the other receiving chemotherapy plus atezolizumab. Biomarker Analysis: Levels of miR375 and miR21 were measured to assess their correlation with treatment outcomes. Duration: The study spanned a specific time frame, observing the patients' responses and survival rates. Key Findings: Survival Rates: The data might show a statistically significant improvement in survival rates in the group receiving atezolizumab. Progression-Free Survival: This group might also demonstrate a longer progression-free survival period compared to the standard chemotherapy group. Biomarker Predictive Value: The study might find that high or low levels of miR375 and miR21 correlate with better or worse outcomes, indicating their potential as predictive biomarkers. Interpretation of Data: Efficacy of Atezolizumab: If the data shows improved outcomes with atezolizumab, it suggests its efficacy in enhancing the effectiveness of chemotherapy. Role of Biomarkers: The correlation between miR375/miR21 levels and treatment outcomes could pave the way for personalized medicine, where treatments are tailored based on individual biomarker profiles. Implications and Usage: Clinical Practice: The results could influence treatment protocols by integrating atezolizumab into standard chemotherapy regimens for certain conditions. Future Research: The findings regarding miR375 and miR21 can lead to further research in biomarker-driven therapy. Personalized Medicine: The study highlights the potential of using biomarkers for tailoring cancer treatments to individual patients. Limitations: The study might have limitations such as sample size, diversity of the participant pool, or the specificity of the condition treated, which should be considered while interpreting the results. In summary, the Lance study provides valuable insights into the role of atezolizumab in chemotherapy and the potential of miR375 and miR21 as predictive biomarkers. This data, subject to peer review and further validation, could significantly impact the field of oncology and personalized medicine.



National and Kapodistrian University of Athens


Survival Analysis, Biomarker Research