Data for: Understanding the Influence of Maternal Hepatitis B E Antibodies Transfer in Neonates: Analyzing Antibodies, myeloid-derived suppressor cells (MDSCs), and their Interplay in the Context of Chronic Hepatitis B and Chronic Hepatitis B-Delta Coi...

Description

This data set consists of 87 distinct samples extracted from the case report, along with three existing tests on the mother of the individual mentioned in the report. All these tests confirm the negative Hepatitis Antibodies status of the mother, indicating that there was no transfer of maternal Hepatitis B E antibodies from the mother to the individual at the time of birth in the reported case. In order to elucidate the positivity of Hepatitis B E Antigen in presented case, I sought to correlate the well-known history of no hepatitis B infection within the family, particularly focusing on the absent immunological makeup transferred from mother. In the case presented, the history of no hepatitis B and the absence of vaccination in the mother correlates with the absence of maternal transfer of Hepatitis B antibodies, respectively with the absence of Hepatitis B E Antibodies at birth. Furthermore, the available data sets provide confirmation of the absence of inflammation resulting from non-subsequent exposure to other hepatitis viruses. This supports the hypothesis that the positivity and persistence of Hepatitis B E Antigen are maintained through various processes. The presence of Hepatitis B E Antigen is associated with the absence of maternal Hepatitis B E antibodies transfer from mother, while the persistence of Hepatitis B E Antigen antigen is maintained by the absence of superinfection with different hepatitis viruses in the presented case. Moreover, there is a strong likelihood that the same process is involved in the positivity of Hepatitis B E in neonates exposed to hepatitis B who were born from HBe antigen-positive mothers. As an alternative to the hypothesis generated, neonates that are exposed to hepatitis B and are born from mothers with positive IgG HBc and HBe antibodies and negative HBs antibodies, have positive Hepatitis B E antibodies (HBe AB) at birth, as a result of acquired immunity by placental transfer of maternal IgG antibodies. This transfer of antibodies is essential for controlling the initial diseases and results in Hepatitis B E antigen neutralization, providing partial defense by secondary antibodies immune response. Therefore, these findings elucidate a novel mechanism responsible for HBe Antigen positivity and HBe antigen neutralization in neonates.

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To establish a link between the absence of typical symptoms of acute liver inflammation, I conducted a analysis in literature and found that the transient presence of MDSCs (4) , along with other immunological factors may also represent a strategy for establishing Hepatitis B and Hepatitis B-Delta chronic infections. The presented data included various tests, such as ALT/AST, Antigen quantitative HBs, platelets, Antibodies HDV IgM and IgG, HBV DNA IU/ml, HDV RNA copies/ml, lymphocytes percentages and absolute count. Values for HBV DNA, HDV RNA, Antigen quantitative HBs are reported as a logarithmic scale base 10. Limited data from childhood were also included and analyzed in this case report. There was also a period of Interferon treatment during childhood, which is considered in this analysis. However, the datasets are no longer available. Additionally at the age of 25, the presented case received another period of treatment with Interferon, which is also included in this analysis. Each period of 1 (one) year of interferon treatment is represented in the graphs. Additionally, based on the presented case, it was found that there was no acute hepatitis manifestation which is typical for Hepatitis Delta. However, the frequency of MDSCs had no obvious difference between neonates (4 ), secondary factors were analyzed. The maternal placental transfer of antibodies was used to determine antibodies’ status of neonates at birth. The status for HBe antibodies at birth can be confirmed through actual testing of mothers’ Hepatitis B E antibodies test. These hypothetical concepts cases, with a single episode of acute liver inflammation experienced in the past, may have different types of hepatitis antibodies that can be established through actual tests and this hypothetical analysis. I present these concepts cases in category 2, with the most common antibodies known to be capable of causing acute liver inflammation, Hepatitis Delta and Hepatitis A. Thus, the hypothetical concept cases in categories 2 and 3 may have either one antibody or both, which suggests different types of hepatitis viruses despite having the same initial antibodies status, as observed in the case presented. This indicates that there may be an acute manifestation contributing to the Hepatitis B E antibodies’ appearance. It is reasonable to hypothesize that these concept cases with hepatitis A antibodies, who experienced a single episode of acute hepatitis and with the same immune status as in presented case were initial asymptomatic Hepatitis B-Hepatitis Delta co-infections. In the case where concepts cases in category 2 have only HDV Antibodies, it is highly plausible to hypothesize that the moment of exposure to acute hepatitis was exposure to HDV superinfection. It is reasonable to hypothesize that these cases were HBe Antigen positive.

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