Cell Reports; Nychyk et al 2021; Figure S1; Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes

Published: 11-05-2021| Version 1 | DOI: 10.17632/8mpc9y9797.1
Kanishka Nilaweera,
Oleksandr Nychyk,
Wiley Barton,
Paul Cotter


This experiment was done to analyze the impact of dietary macronutrients on body weight and tissue partitioning in relation to plasma IGF-1 levels. In total we used 18 different diets and tested these on males of one mouse strain (C57BL/6). This file contains body weight and the correlation between IGF-1 and body/tissue weight of male C57BL/6 mice exposed one of 18 different diets. Body weight was recorded after 6 weeks and at the end of the treatment period. Linear regression analysis was conducted between individual tissues and body weight or IGF-1 hormone. The tissue weights are from dissection at the end of the experiment and IGF-1 levels are from plasma. Dietary treatments consisted of three different levels of dietary fat (20, 40 and 55% by energy) combined with three different levels of protein (10, 20 and 30% by energy) with either casein (CAS) or whey protein isolate (WPI). Full details of the dietary compositions can be found in the supplementary table 1. Complete meta-data are in the meta-data tab of the file. Body weight: means for each diet derived from individual values and presented in Figure S1A. Regression coefficients (R2) and p-values are listed for each comparison and these individual values presented as heatmap in Figure S1B.