Cell Reports; Nychyk et al 2021; Figure S1; Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes

Published: 11-05-2021| Version 1 | DOI: 10.17632/8mpc9y9797.1
Contributors:
Kanishka Nilaweera,
Oleksandr Nychyk,
Wiley Barton,
Paul Cotter

Description

This experiment was done to analyze the impact of dietary macronutrients on body weight and tissue partitioning in relation to plasma IGF-1 levels. In total we used 18 different diets and tested these on males of one mouse strain (C57BL/6). This file contains body weight and the correlation between IGF-1 and body/tissue weight of male C57BL/6 mice exposed one of 18 different diets. Body weight was recorded after 6 weeks and at the end of the treatment period. Linear regression analysis was conducted between individual tissues and body weight or IGF-1 hormone. The tissue weights are from dissection at the end of the experiment and IGF-1 levels are from plasma. Dietary treatments consisted of three different levels of dietary fat (20, 40 and 55% by energy) combined with three different levels of protein (10, 20 and 30% by energy) with either casein (CAS) or whey protein isolate (WPI). Full details of the dietary compositions can be found in the supplementary table 1. Complete meta-data are in the meta-data tab of the file. Body weight: means for each diet derived from individual values and presented in Figure S1A. Regression coefficients (R2) and p-values are listed for each comparison and these individual values presented as heatmap in Figure S1B.

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