The Multifaceted Roles of Male Absent on the First (MOF) in Metabolism
Histone acetylation is a well-preserved post-translational modification that plays a crucial role in regulating gene expression, chromatin structure, and cellular behaviors. Among the various histone acetyltransferases, MOF (also known as MYST1 or KAT8) exhibits a high degree of conservation across species, ranging from Drosophila to humans. MOF is responsible for acetylating histone 4 lysine 16 as well as numerous non-histone proteins, thereby exerting a wide range of biological functions. The academic literature has extensively reviewed the role of MOF in orchestrating outcomes at the intersection of oncogenesis, DNA damage response, cellular proliferation, and stem cell development. Increasingly, a growing body of evidence has demonstrated the correlation between MOF and metabolism. MOF consistently plays a role in various aspects of metabolism, including carbohydrate and lipid metabolism, as well as metabolic disorders such as disturbances in glucose homeostasis, obesity, and non-alcoholic fatty liver disease. Furthermore, MOF-mediated metabolism also assumes crucial roles in well-established biological processes such as oncogenesis and stem cell differentiation. These diverse phenotypes collectively indicate that the influence of MOF on metabolism is pervasive across multiple organs and assumes indispensable functions in various contexts.
National Natural Science Foundation of China