Systematic Review Dataset on Environmental Enrichment Effects on BDNF in ASD Models
Description
We have compiled a dataset for a systematic review on the effect of environmental enrichment (EE) on brain-derived neurotrophic factor (BDNF) activity in animal models of autism spectrum disorder (ASD). This dataset allows for a comprehensive analysis of EE's impact on BDNF expression and related behavioral outcomes, focusing on variability across experimental conditions and study designs. The dataset includes articles identified through systematic searches in multiple databases (PubMed, Scopus, and Web of Science), organized across key stages of the review process: - Keywords and Search Strategies: This document includes all search terms and Boolean operators used across databases to ensure transparency and reproducibility. - All retrieved articles: A complete list of studies identified using pre-defined search strategies. - Articles after removing duplicates: A refined dataset excluding duplicate records. Retained articles after Title and Abstract screening: Results of title and abstract screening based on inclusion and exclusion criteria. - Excluded studies after Full-text screening and reasons for exclusion. The results revealed variability in the effects of EE on BDNF activity and behavioral outcomes. Factors such as the type of ASD model, EE protocols, sex of the animals, and brain regions examined significantly influenced the observed outcomes. Increased BDNF expression emerged as a key mechanism underlying EE’s impact on ASD-associated behaviors.
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This systematic review, following PRISMA 2020 guidelines (Page et al., 2021), evaluated the effects of environmental enrichment (EE) on brain-derived neurotrophic factor (BDNF) activity and behavioral outcomes in rodent models of autism spectrum disorder (ASD). A literature search was conducted in April 2024 using PubMed, Scopus, and Web of Science, with no date or language restrictions. Two authors independently screened studies based on strict eligibility criteria, focusing on animal intervention studies with controlled groups and EE protocols targeting social, motor, sensory, or cognitive domains. Exclusion criteria included non-primary studies, non-intervention studies, and studies without control groups.