European consensus for the diagnosis of MCI _QUADAS-II assessment

Published: 31 October 2023| Version 2 | DOI: 10.17632/8sxf8tvwgm.2
Cristina Festari, Matteo Cotta Ramusino, Federico Massa, Stefania Orini, Valentina Nicolosi, Federica Gandolfo, Flavio Nobili, Giovanni Frisoni, for the European Inter-Societal Consensus on the Biomarker-Based Diagnosis of Dementia


Using a modified Delphi procedure, a European task force is defining a diagnostic workflow for etiologicical and biomarker-based diagnosis of neurocognitive disorders, in which expert expertise fills evidence gaps for validity and prioritization of biomarkers. The panel of experts is asked to answer a Delphi questionnaire and justify their answers with evidence from the literature. We then provided the experts with data on the diagnostic accuracy of biomarkers (MRI, amyloid PET, tau and FDG, MIBG scintigraphy, DaT-SPECT, EEG and polysomnography) in predicting clinical progression from prodromal stages to mild dementia in neurocognitive disorders. Keywords used for literature search in Medline database are in the .pdf file. We assessed the quality of evidence from the included literature using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). The data were recorded in the attached Excel sheet.



IRCCS Centro S Giovanni di Dio Fatebenefratelli


Literature Review