MDR-TB patients Data in the six geopolitical zones of Nigeria from January 2013 to December 2017

Published: 26-03-2021| Version 1 | DOI: 10.17632/946t6rjbyj.1
Contributors:
Kingsley Nwosu,
Opeyemi Opayemi,
Ifeoma Nduka,
Sunday Nduka

Description

The aim of the study was to determine the rate of distribution, risk factors and treatment outcomes associated with multidrug-resistant tuberculosis (MDR-TB) in patients admitted to different specialized treatment centres in Nigeria between January, 2013 and December, 2017. This was a multi-center, hospital-based retrospective study designed to identify the pattern of prevalence, the factors predisposing individuals and the outcome of treatment of multidrug resistant tuberculosis in Nigeria. The medical records of bacteriologically and clinically confirmed MDR - TB patients that were registered, admitted and treated in twelve special MDR-TB treatment centres from across the six geopolitical zones in Nigeria between January, 2013 and December, 2017 were used for the study. These patients’ folders/files were reviewed and data were collected using a purposively designed proforma. Treatment outcome of patient’s were determined and recorded in their medical records by the health team following standard WHO definitions of MDR-TB treatment performance indicator. The MDR TB treatment centers’ pharmacists were used as research assistants and they were trained on how to collect data into the Microsoft excel sheet proforma at the quarterly/annual MDR TB logistic officers meeting held every three months before the commencement of data collection. The participants for this study were recruited from the various specialized MDR TB treatment centers in Nigeria. Two MDR - TB treatment centers were selected from each of the six geopolitical zones based on the order of establishment. The selected hospitals and their zonal distributions include: South East (Federal Medical Centre, Owerri treatment center and Mile 4 treatment center, Abakiliki); South South, (University of Port Harcourt Teaching Hospital treatment centre, Port Harcourt and University of Uyo Teaching Hospital treatment center, Uyo); South West (University College Hospital treatment center, Ibadan and Sacred Heart Hospital treatment center, Abeokuta); North West (National Tuberculosis and Leprosy Training center, Zaria and Sokoto treatment center, Sokoto); North East (Abubakar Tafawa Balewa University Teaching Hospital treatment center, Bauchi and Taraba State Specialist Hospital treatment center, Jalingo); North Central (St Vincent Alade treatment centre, Benue and Jos University Teaching Hospital treatment center, Jos ). The data collected from this study was entered into a Microsoft excel sheet and analyzed using statistical package for social sciences (version20). Descriptive statistics was used to analyze the demographics, patients’ clinical characteristics and clinical outcomes. The percentage distribution of MDR-TB at the geopolitical zones in Nigeria were determined. Univariate logistic regression analysis was used to determine the effect of the risk factors on MDR – TB. Statistically significant values were accepted at p< 0.05. The treatment outcome were categorized into four gruops

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This was a multi-center, hospital-based retrospective study designed to identify the pattern of prevalence, the factors predisposing individuals and the outcome of treatment of multidrug resistant tuberculosis in Nigeria. The medical records of bacteriologically and clinically confirmed MDR - TB patients that were registered, admitted and treated in twelve special MDR-TB treatment centres from across the six geopolitical zones in Nigeria between January, 2013 and December, 2017 were used for the study. These patients’ folders/files were reviewed and data were collected using a purposively designed proforma. Treatment outcome of patient’s were determined and recorded in their medical records by the health team following standard WHO definitions of MDR-TB treatment performance indicator. The MDR TB treatment centers’ pharmacists were used as research assistants and they were trained on how to collect data into the Microsoft excel sheet proforma at the quarterly/annual MDR TB logistic officers meeting held every three months before the commencement of data collection. The participants for this study were recruited from the various specialized MDR TB treatment centers in Nigeria. Two MDR - TB treatment centers were selected from each of the six geopolitical zones based on the order of establishment. The selected hospitals and their zonal distributions include: South East (Federal Medical Centre, Owerri treatment center and Mile 4 treatment center, Abakiliki); South South, (University of Port Harcourt Teaching Hospital treatment centre, Port Harcourt and University of Uyo Teaching Hospital treatment center, Uyo); South West (University College Hospital treatment center, Ibadan and Sacred Heart Hospital treatment center, Abeokuta); North West (National Tuberculosis and Leprosy Training center, Zaria and Sokoto treatment center, Sokoto); North East (Abubakar Tafawa Balewa University Teaching Hospital treatment center, Bauchi and Taraba State Specialist Hospital treatment center, Jalingo); North Central (St Vincent Alade treatment centre, Benue and Jos University Teaching Hospital treatment center, Jos ).