Therapeutic Effects of Traditional Chinese Medicine in Coronavirus Disease-19
Herb Preparation and Treatment BuFeiQuWen decoction was designed by our Chinese-herb consulting physician team according to the theory of Chinese medicine and our clinical experience. A total of 13 different kinds of herbs with 5-20g of each made up the formula, including 3 monarch herbs, 8 ministerial herbs, and 2 adjuvant herbs were shown in Table 1. Five to 7 packets of BuFeiQuWen were submerged in cold water 3cm-5cm above the surface for 30 minutes, and then put the soaked herbs into the decoction machine (YJD30-GL, DONGHUAYUAN MEDICAL, China) with the water at 110℃ for 20 min. Decoction was separated 100ml per sachet after cooling, and stored in refrigerator at 4℃. The decoction amount of each packet was 300 ml, and water loss during processing was 2500ml. So the water amount of decocting herbs was calculated as number of packets×300ml+2500ml. The decoction was administered 100ml each time, three times a day throughout the hospital stay. Patients For this retrospective, of the 78 coronavirus disease 2019 (COVID-19) patients diagnosed according to WHO interim guidance were recruited from Jan 20, 2020 to Mar 8, 2020. Eighteen of those patients took the Traditional Chinese Medicine (TCM), BuFeiQuWen decoction (补肺祛瘟饮) as the TCM group versus 60 cases by standard Chinese medicine treatment in the control group. We obtained demographic, epidemiological, clinical signs and symptoms, laboratory, and outcome data from patients' medical records. The protocol was approved by the Ethics Committee of Guizhou Provincial People’s Hospital. Informed consent was obtained from all the enrolled patients before data were collected retrospectively. Exposure history and clinical classification According to WHO Interim Guidance, the case in this study was defined as any one with exposure history and consistent with any two clinical manifestations and the pathogenic evidence. Exposure history: (1)Input, within 14 days before the onset of the disease, there were tourism or residence histories of Wuhan or its surrounding areas, or other communities with confirmed cases; (2) Close contacts, within 14 days before the onset of the disease, there were contacts with confirmed cases of COVID-19 or aggregation in an enclosed environment (such as a family house, a construction site, an office, etc.). Clinical classification: (1) Mild, the clinical symptoms were mild, with no radiographic findings; (2) Moderate, with fever, cough and other respiratory symptoms, imaging findings of pneumonia; (3) Severe, with dyspnea, respiratory frequency≥30/min, blood oxygen saturation≤93%, partial pressure of arterial oxygen to fraction of inspired oxygen ratio <300, and/or lung infiltrates >50% within 24 to 48 hours.