PlexinA4-Semaphorin3A mediated crosstalk between main cortical interneuron classes is required for superficial interneurons lamination

Published: 27-01-2021| Version 2 | DOI: 10.17632/985rz5v3xs.2
Contributors:
Greta Limoni,
Mathieu Niquille

Description

We demonstrate that the two main classes of interneurons (INs) communicate during cortical development. MGE-derived INs first colonize deep layers and serve as guidepost for later-arriving HTR3A+ INs. This process relies on PlexinA4 and Semaphorin3A signaling and is critical for the proper distribution of inhibitory neurons across layers. Data here is files containing manual counting of neurons in the mouse somatosensory cortex at different ages (details are included in each of them). Data in 3 contains area measurements of growth cones after embryonic dissociated cell cultures. Data in 4 and 6 contains dynamic tracking of cells after time-lapse imaging. For each excel file, an associated prism file contains related statistical analyses.

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