Data for: Development of Composite Nanoparticles Composed of Silica-Coated Nanorods and Single Nanometer-Sized Gold Nanoparticles Toward a Novel X-ray Contrast Agent
Description
Gold is expected to function as a high contrast agent for X-ray computed tomography imaging as it has high X-ray absorptivity owing to a large atomic number compared to commercial materials such as barium and iodine. The present work proposes a preparation method for core-shell nanoparticles composed of Au formation with a nanorod structure (AuNR), SiO2, and a single nanometer-sized Au (sAu), toward imaging and photothermal therapy. The AuNRs were silica-coated using a sol-gel method (AuNR/SiO2). Thiol groups were introduced onto the AuNR/SiO2 nanoparticle surface (AuNR/SiO2-SH). A thiol-terminated PEG aqueous solution and sAu nanoparticle colloidal solution were added in turn to the AuNR/SiO2-SH dispersed in EtOH. The CT value of the composite nanoparticles solution was 702 HU. The CT values in tissues immediately increased after injection into a mouse. Their blood retention times were 3–6 h, much longer than the few minutes of a commercial X-ray contrast agent.