Data from Medullary and C3-C4 Propriospinal Pathways

Description

Data related to pnas article entitled "Medullary and C3-C4 Propriospinal Pathways Underlying Mammalian Forelimb Movement Control" Jindal et al. Our study identifies a conserved medullary network, comprising the Lat-RM and CauM, underlying forelimb movement control across species, while also revealing cortical differences potentially driven by task demands or inter-species neuroanatomical variations. This network follows an orderly organization of cortical connections along the ventro-medio-dorsal axis of the medulla. We provide the first functional mapping of the human C3–C4 propriospinal pathway, which exhibits anatomically segregated connectivity with brainstem nuclei, cerebellum, and motor cortex. Together, our findings suggest an indirect motor pathway involving both the reticulospinal tract and the C3–C4 propriospinal system that contributes to fine hand motor control, and highlight the central role of the propriospinal system in integrating reticular, cortical, and cerebellar inputs to support this function.

Steps to reproduce

Data and code necessary to reproduce the results in Jindal et al. (PNAS: pnas.2518217123) are organized and publicly/shared. Shared materials include (i) time-series data, (ii) individual-level functional connectivity (FC) values, (iii) MATLAB scripts used to compute FC, and (iv) activation maps corresponding to those reported in the Supplementary Materials.

Institutions

• University of California Riverside

  CA, Riverside
• University of Florida

  FL, Gainesville

Categories

Funders

• National Institute of Neurological Disorders and Stroke

  National Institutes of Health

  Maryland, United States

  Grant ID: R01NS131227
• Florida Department of Health

  Florida, United States

  Grant ID: 23K07

Licence