Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease
Compounds of the general formula CC1=CC2=C(C=C1)N(CC1=CC=CC=C1)C=C2CN1CCCCC1 (comp. 2) with different substituents at the pending aromatic ring (comp. 9 = p-Me; comp. 10 = m-Cl; comp. 11 = p-Cl; comp. 12 = p-F; comp. 13 = o-NO2; comp. 14 = m-NO2), were tested as voltage-gated Ca2+ channels blockers and protein phosphatase 2A-activating drugs. The mutual effect on these two biological targets closely implicated in the Alzheimer's disease progression induced neuroprotection in a model of Tau hyperphosphorylation.