Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease

Name: Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease
Creator: de los Ríos Cristóbal
Published: 2018-04-12T12:20:42.736Z
Keywords: Pharmaceutical Chemistry

Cristóbal, de los Ríos; Viejo, Lucia; Gonzalez, Dorleta; Arribas, Raquel L; Lajarin-Cuesta, Rocio

doi:10.17632/9n2kdhr4nk.1

Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease

Published: 12 April 2018| Version 1 | DOI: 10.17632/9n2kdhr4nk.1

Contributors:

de los Ríos Cristóbal, Lucia Viejo, Dorleta Gonzalez, Raquel L Arribas, Rocio Lajarin-Cuesta

Description

Compounds of the general formula CC1=CC2=C(C=C1)N(CC1=CC=CC=C1)C=C2CN1CCCCC1 (comp. 2) with different substituents at the pending aromatic ring (comp. 9 = p-Me; comp. 10 = m-Cl; comp. 11 = p-Cl; comp. 12 = p-F; comp. 13 = o-NO2; comp. 14 = m-NO2), were tested as voltage-gated Ca2+ channels blockers and protein phosphatase 2A-activating drugs. The mutual effect on these two biological targets closely implicated in the Alzheimer's disease progression induced neuroprotection in a model of Tau hyperphosphorylation.

Data for: Substituent effect of N-benzylated gramine derivatives that up-regulate the PP2A-leaded phosphatase activity and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease

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