Development and Validation of Stability Indicating HPLC Method for the Determination of Impurities in the Sterile Mixture of Cefoperazone and Sulbactam

Published: 13 August 2019| Version 1 | DOI: 10.17632/9p9pzf77gy.1
TManikya sastry,
Satyaveni Sunkara


Cefoperazone Sulbactam injection is a cephalosporin antibiotic with a β-lactamase inhibitor used in the treatment for Intra abdominal infections, Urinary track infections, surgical infections, etc. The combination is not official in any of the pharmacopeias for their content and impurities determination. The present study involves the development of a simple, rapid, accurate, sensitive and stability indicating RP-HPLC method for the quantitative estimation of Cefoperazone Sulbactam mixture and its impurities in bulk and pharmaceutical dosage forms.