Data for: Leptin – a new marker for development of post-transplant diabetes mellitus?

Published: 27-07-2018| Version 1 | DOI: 10.17632/b2npfvgrb3.1
Contributors:
Ivana Dedinská,
Peter Galajda,
Juraj Miklušica,
Petra Skálová,
Lea Kováčiková,
Marián Mokáň,
Nadežda Mäčková,
Daniela Kantárová,
Ľudovít Laca,
Karol Graňák

Description

Introduction: Obese patients have increased leptin production and selective resistance to its central anti-adipogenic effects, yet its pro-inflammatory immunostimulating effects persist. Material and Methods: In a group of 70 patients who underwent primary kidney transplantation (KT) we examined adiponectin and leptin levels at the time of KT and 6 months post-transplantation. Patients with diabetes mellitus type 1 or type 2 at the time of KT were excluded from the study. Results: We found that leptin levels significantly increased during the post-transplant period (P = 0.0065). Overall, leptin levels were positively correlated with the level of triacylglycerols, post-transplant diabetes mellitus (PTDM) development and acute rejection (AR). We discovered that, in particular, high leptin levels were associated with AR [OR 2.1273; 95%CI 1.0130-4.4671 (P = 0.0461)] and PTDM development [OR 7.200; 95%CI 1.0310-50.2836 (P = 0.0465)], whereas, low adiponectin levels represent a risk factor for the development of insulin resistance [HR 38.6135; 95%CI 13.3844-67.7699 (P <0.0001)] and obesity [HR 3.0821; 95%CI 0.8700-10.9192 (P = 0.0053)]. Conclusion: We found that a high serum concentration of leptin before KT is associated with both PTDM development and AR and merits further investigation in relation to KT.

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