An unconventional integrin 3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells. Abd Hamid et al.

Name: An unconventional integrin 3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells. Abd Hamid et al.
Creator: Megat Abd Hamid
Published: 2021-12-13T16:54:57.943Z
Keywords: Immunology, Cancer

Abd Hamid, Megat; Cespedes, Pablo; Liang, Zhu; Ling Felce, Suet; Jin, Chen; Khalid-Alham, Nasullah; Hester, Svenja; Kanellakis, Nikolaos; Maldonado-Perez, David; Teague, Renuka; Cerundolo, Lucia; Yao, Xuan; Chen, Jili; Kessler, Benedikt; Fernandes, Ricardo; Verrill, Clare; Dustin, Michael; Fischer, Roman; Peng, Yanchun; Dong, Tao

doi:10.17632/b2xdk4h5xm.1

An unconventional integrin 3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells. Abd Hamid et al.

Published: 13 December 2021| Version 1 | DOI: 10.17632/b2xdk4h5xm.1

Contributors:

Megat Abd Hamid,

,

Suet Ling Felce,

Chen Jin,

Nasullah Khalid-Alham,

Svenja Hester,

Nikolaos Kanellakis,

David Maldonado-Perez,

Renuka Teague,

Lucia Cerundolo,

Xuan Yao,

Jili Chen,

Benedikt Kessler,

Ricardo Fernandes,

Clare Verrill,

Michael Dustin,

Roman Fischer,

Yanchun Peng,

Tao Dong

Description

Paired CD103+ and CD103- SSX2-specific CD8 T cells and paired CD103+ and CD103- NYESO1-specific CD8 T cells were activated for 0, 3 or 6 hours with anti-CD3/CD28 stimulation. Cells were then lysed in 1% NP40 cell lysis buffer before proteins pelleted and snap freezes. Dried proteins were digested into peptide before analysed by liquid chromatography tandem mass spectrometry (LC-MS/MS) using Ultimate 3000 UHPLC (ThermoFisher Scientific) connected to an Orbitrap Fusion Lumos Tribrid (ThermoFisher Scientific).

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University of Oxford

An unconventional integrin 3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells. Abd Hamid et al.

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