SMARCD2 neutrophil chemotaxis

Published: 27 October 2020| Version 1 | DOI: 10.17632/b94vwmvkz2.1
Contributors:
Ina Schim van der Loeff,
Evelien Sprenkeler,
Anton Tool,
Mario Abinun,
Angela Grainger,
Karin Engelhardt,
Michel van Houdt,
Hans Janssen,
Taco Kuijpers,
Sophie Hambleton

Description

Defective chemotaxis of SMARCD2-deficient patient cells assessed with TaxiScan. Travel control and patient cells stimulated with C5a (100 nM; Video 1 = travel control and 2 = patient) or fMLF (100 nM; Video 3 = travel control and 4 = patient). TAXIScan analysis was performed with an EZ-TAXI scan. Data accompany the manuscript "Specific granule deficiency and myelodysplasia caused by a homozygous splice site mutation in SMARCD2" by Ina Schim van der Loeff, Evelien G.G. Sprenkeler, Anton T.J. Tool, Mario Abinun, Angela Grainger, Karin R. Engelhardt, Michel van Houdt, Hans Janssen, Taco W. Kuijpers, and Sophie Hambleton, to be published in the Journal of Allergy and Clinical Immunology.

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